Blocking a key enzyme may reverse memory loss
Many of the genes required to form new memories are shut down by a
genetic blockade in the brains of Alzheimer’s patients, contributing to the cognitive decline seen in those patients.
MIT researchers have now shown that they can reverse that memory loss
in mice by interfering with the enzyme that forms the blockade. The enzyme,
known as HDAC2, turns genes off by condensing them so tightly that they
can’t be expressed. In this study, the researchers used a large protein fragment
to interfere with HDAC-2, but they plan to seek smaller molecules that would be easier to deploy as drugs.
September is National Ovarian Cancer Awareness Month
Ovarian Cancer is one of the deadliest
of women’s cancers, but if detected
in its earliest stage, the five-year
survival rate is more than 93 percent.
It typically strikes those in their 50s
and 60s, with many having a family
history of the disease.
Symptoms may include bloating,
nausea, pelvic pain, gas, abnormal
vaginal bleeding, extreme fatigue,
change of bladder habits and weight
gain. Tests include a transvaginal ultrasound and/or a CA-125 blood test.
For men, September is National Prostate Awareness Month
is the most common non-skin
cancer among American men
and usually grows slowly. Most men with the disease
are older than 65 years and do not die from the disease.
African-American men and those with a family history of the disease are at greater risk.
While some men do not have symptoms, others with the cancer may
experience difficulty starting urination, frequent urination (especially at night),
weak or interrupted flow of urine, and blood in the urine or semen. Screening
for the disease includes a digital rectal exam and a PSA blood test.
Intensive blood pressure control reduces risk of mild cognitive
impairment (MCI) and the combined risk of MCI and dementia
A recent large-scale, long – term
study reported at the Alzheimer’s
Association International Conference
2018 in Chicago, showed that aggressive lowering of systolic blood pressure reduces risk of mild cognitive impairment (MCI) and the combined risk of MCI and dementia.
Systolic pressure is the top number on
a blood pressure reading and measures
the maximum pressure your heart exerts
while beating. In general, 120/80
is a normal blood pressure reading.